Predictors of treatment non-response for depression in a sample of female adolescents with risk-taking and self-injurious behavior: a one year follow-up
Objective - Depressive disorders (DD) are highly prevalent among adolescents. While up to 60 % do not respond to treatment, evidence on predictors of treatment non-response in this age group is mixed, impeding meaningful clinical implications. Drawing on a consecutive clinical cohort of adolescents...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2023
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| In: |
Journal of affective disorders
Year: 2023, Volume: 324, Pages: 129-135 |
| ISSN: | 1573-2517 |
| DOI: | 10.1016/j.jad.2022.12.073 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jad.2022.12.073 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0165032722014331 
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| Author Notes: | Jasper Vöckel, Christine Sigrist, Michael Kaess, Julian Koenig |
| Summary: | Objective - Depressive disorders (DD) are highly prevalent among adolescents. While up to 60 % do not respond to treatment, evidence on predictors of treatment non-response in this age group is mixed, impeding meaningful clinical implications. Drawing on a consecutive clinical cohort of adolescents with risk taking and self-injurious behavior, the present study aimed to identify predictors of treatment non-response for female DD in a naturalistic one year follow-up. - Methods - The sample comprised female adolescents with verified DD (n = 152). Patients underwent assessments at baseline (T0) and follow-up (T1). Sociodemographic factors (e.g., age), clinical measures (e.g., symptom severity, trauma), and treatment variables (e.g. number of psychotherapy sessions), were analyzed as potential predictors of treatment non-response in unadjusted analyses and analyses adjusting for treatment intensity and age at baseline. Treatment response was defined based on not fulfilling formal diagnosis for DD at follow-up (52.3 %; n = 80) or the 50 % decrease in self-reported depressive symptoms (21.1 %; n = 32) from T0 to T1. - Results - Greater depressive and overall symptom severity, greater frequency of self-injuries, history of suicide attempts and history of childhood trauma at T0 were robustly associated with treatment non-response based on diagnostic interviews. Only a lower number of siblings was robustly associated with treatment non-response based on self-reports. - Limitations - Findings may not generalize to other treatment settings. - Conclusion - Collectively, our results highlight overall symptom severity as significant predictor of treatment non-response in female adolescents with depression. Methodological differences (interviews versus self-reports) and potential implications from these findings for clinical practice are discussed. |
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| Item Description: | Online verfügbar: 29. Dezember 2022 Gesehen am 09.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1573-2517 |
| DOI: | 10.1016/j.jad.2022.12.073 |