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The IGF/IGFBP system in relation to macroscopic bone architecture in pediatric renal transplant patients

The post-transplant bone disease of the peripheral skeleton in pediatric renal transplant recipients is characterized by an inadequately thin bone cortex in relation to muscular force. A major hormonal modulator of periosteal growth is the insulin-like growth factor (IGF)/IGF binding protein (IGFBP)...

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Bibliographic Details
Main Authors: Choukair, Daniela (Author) , Rüth, Eva-Maria (Author) , Blum, Werner F. (Author) , Mohan, Subburaman (Author) , Weber, Lutz T. (Author) , Tönshoff, Burkhard (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Pediatric nephrology
Year: 2010, Volume: 25, Issue: 4, Pages: 659-667
ISSN:1432-198X
DOI:10.1007/s00467-009-1405-5
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00467-009-1405-5
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00467-009-1405-5
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Author Notes:Daniela Kiepe, Eva-Maria Rüth, Werner F. Blum, Subburaman Mohan, Lutz T. Weber, Burkhard Tönshoff
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Summary:The post-transplant bone disease of the peripheral skeleton in pediatric renal transplant recipients is characterized by an inadequately thin bone cortex in relation to muscular force. A major hormonal modulator of periosteal growth is the insulin-like growth factor (IGF)/IGF binding protein (IGFBP) system. We therefore hypothesized that the reduced cortical thickness in these patients may be due to functional IGF deficiency.
Item Description:Online veröffentlicht am 22. Dezember 2009
Gesehen am 09.03.2023
Physical Description:Online Resource
ISSN:1432-198X
DOI:10.1007/s00467-009-1405-5

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