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Enhanced dendritic action potential backpropagation in parvalbumin-positive basket cells during sharp wave activity

In this study two-photon imaging and single cell electrophysiological measurements were carried out in PV+ hippocampal interneurons to compare the dendritic calcium dynamics of somatically evoked backpropagating action potentials (BAPs) and in vitro sharp wave oscillation (SPW) activated BAPs at dif...

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Main Authors: Chiovini, Balázs (Author) , Turi, Gergely F. (Author) , Katona, Gergely (Author) , Kaszás, Attila (Author) , Erdélyi, Ferenc (Author) , Szabó, Gábor (Author) , Monyer, Hannah (Author) , Csákányi, Attila (Author) , Vizi, E. Sylvester (Author) , Rózsa, Balázs (Author)
Format: Article (Journal)
Language:English
Published: 3 November 2010
In: Neurochemical research
Year: 2010, Volume: 35, Issue: 12, Pages: 2086-2095
ISSN:1573-6903
DOI:10.1007/s11064-010-0290-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11064-010-0290-4
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Author Notes:Balázs Chiovini, Gergely F. Turi, Gergely Katona, Attila Kaszás, Ferenc Erdélyi, Gábor Szabó, Hannah Monyer, Attila Csákányi, E. Sylvester Vizi, Balázs Rózsa
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Summary:In this study two-photon imaging and single cell electrophysiological measurements were carried out in PV+ hippocampal interneurons to compare the dendritic calcium dynamics of somatically evoked backpropagating action potentials (BAPs) and in vitro sharp wave oscillation (SPW) activated BAPs at different distances from the soma. In the case of 300 μm thick, non-oscillating slices, the BAP-evoked Ca(2+) (BAP-Ca(2+)) influx propagated along the dendritic tree in a non-uniform manner and its amplitude gradually reduced when measured at more distal regions. In contrast to the evoked BAP-Ca(2+)s, the spontaneous SPW-induced Ca(2+) influx had only a small distance-dependent decrement. Our results suggest that similarly to nicotinic acetylcholine receptor activation, synaptic activity during hippocampal SPWs increases AP backpropagation into distant dendritic segments. Bath application of Nimodipine, a specific Ca(2+) channel blocker and tetrodotoxine decreased the amplitude of the somatically evoked Ca(2+) influx, which suggests that L-type Ca(2+) channels play an important role both during somatically evoked and SPW-induced BAPs.
Item Description:Gesehen am 09.03.2023
Physical Description:Online Resource
ISSN:1573-6903
DOI:10.1007/s11064-010-0290-4

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