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CIC reduces xCT/SLC7A11 expression and glutamate release in glioma

Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived glioma lines, RNA-sequencing and bioinformatic analysis of...

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Main Authors: Park, Jongwhi (Author) , Kilic, Omer (Author) , Deo, Minh (Author) , Jimenez-Cowell, Kevin (Author) , Demirdizen, Engin (Author) , Kim, Hyunggee (Author) , Turcan, S̨evin (Author)
Format: Article (Journal)
Language:English
Published: 16 January 2023
In: Acta Neuropathologica Communications
Year: 2023, Volume: 11, Pages: 1-12
ISSN:2051-5960
DOI:10.1186/s40478-023-01507-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40478-023-01507-y
Verlag, kostenfrei, Volltext: https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-023-01507-y
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Author Notes:Jong-Whi Park, Omer Kilic, Minh Deo, Kevin Jimenez-Cowell, Engin Demirdizen, Hyunggee Kim and Şevin Turcan
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Summary:Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived glioma lines, RNA-sequencing and bioinformatic analysis of publicly available databases, we investigated how CIC loss- or gain-of-function regulates its downstream targets, cell proliferation and glutamate release. Our results indicate an increased frequency of CIC truncating mutations in oligodendroglioma during progression. ...
Item Description:Gesehen am 15.11.2023
Physical Description:Online Resource
ISSN:2051-5960
DOI:10.1186/s40478-023-01507-y

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