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Long-term outcome 10 years or more after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with ulcerative colitis

Purpose: The aim of this study was to assess quality of life (QOL) in a long-term follow-up of patients with ulcerative colitis (UC) 10 years and more after ileal pouch–anal anastomosis (IPAA) to correlate these results with pouch function and to assess the long-term pouch failure rate. Methods: In...

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Main Authors: Leowardi-Bauer, Christine (Author) , Hinz, Ulf (Author) , Tariverdian, Mirjam (Author) , Kienle, Peter (Author) , Herfarth, Christian (Author) , Ulrich, Alexis (Author) , Kadmon, Martina (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Langenbeck's archives of surgery
Year: 2010, Volume: 395, Issue: 1, Pages: 49-56
ISSN:1435-2451
DOI:10.1007/s00423-009-0479-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00423-009-0479-7
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Author Notes:Christine Leowardi, Ulf Hinz, Mirjam Tariverdian, Peter Kienle, Christian Herfarth, Alexis Ulrich, Martina Kadmon
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Summary:Purpose: The aim of this study was to assess quality of life (QOL) in a long-term follow-up of patients with ulcerative colitis (UC) 10 years and more after ileal pouch–anal anastomosis (IPAA) to correlate these results with pouch function and to assess the long-term pouch failure rate. Methods: In a unicentric study, 294 consecutive patients after IPAA between 1988 and 1996 were identified from a prospective database. QOL was evaluated according to the validated Gastrointestinal Quality of Life Index (GIQLI). Results: Overall median follow-up was 11.5 years. Thirty-seven patients experienced pouch failure (12.6%). The rates of ileal pouch success after 5, 10 and 15 years were 92.3%, 88.7% and 84.5%. According to the GIQLI, patients with a functioning pouch achieved a mean score of 107.8, reflecting a decrease of QOL of 10.8% compared to a healthy population. There were significant negative correlations between QOL and an age of >50 years (p < 0.05), pouchitis, perianal inflammation and increased stool frequency (p < 0.0001). Conclusions: QOL and functional results of patients with UC 10 years or more after IPAA were acceptable; however, those were reduced when compared to a healthy population. Pouch failure rate still increases up to 15.5% 15 years after IPAA. This result represents an important issue in providing patients with comprehensive preoperative information.
Item Description:Online veröffentlicht: 12. März 2009
Gesehen am 13.03.2023
Physical Description:Online Resource
ISSN:1435-2451
DOI:10.1007/s00423-009-0479-7

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