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CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients

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Background: This is the first prospective case-control study that evaluates the expression of tumour-specific antigens on circulating microparticles (MP) in breast cancer patients and in women with benign breast tumour. Materials and Methods: MP were determined by flow cytometry in patients with bre...

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Main Authors: Liebhardt, Susanne (Author) , Ditsch, Nina (Author) , Nieuwland, Rienk (Author) , Rank, Andreas (Author) , Jeschke, Udo (Author) , Koch auf Rohrbach, Franz von (Author) , Friese, Klaus (Author) , Toth, Bettina (Author)
Format: Article (Journal)
Language:English
Published: June 30, 2010
In: Anticancer research
Year: 2010, Volume: 30, Issue: 5, Pages: 1707-1712
ISSN:1791-7530
Online Access:Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/30/5/1707
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Author Notes:Susanne Liebhardt, Nina Ditsch, Rienk Nieuwland, Andreas Rank, Udo Jeschke, Franz Von Koch, Klaus Friese and Bettina Toth
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Summary:Background: This is the first prospective case-control study that evaluates the expression of tumour-specific antigens on circulating microparticles (MP) in breast cancer patients and in women with benign breast tumour. Materials and Methods: MP were determined by flow cytometry in patients with breast cancer (n=34; T1 (n=19) and T2 (n=15)) and women with benign breast tumour (n=19). Results: Patients with lymph node metastases (N1, n=9) showed significantly higher numbers of annexin V+ MP (p=0.042), CD66+ MP (p=0.045), BCRP1+ MP (breast cancer resistance protein) (p=0.025) and Hsp27+ MP (p=0.034) than controls. Furthermore, T1 patients had significantly higher levels of annexin V+ MP (p=0.004), CD66+ MP (p=0.025), BCRP1+ MP (p=0.008) and Hsp27+ MP (p=0.02) than controls. Conclusion: Significant differences are present between breast cancer patients with lymph node metastases and controls concerning annexin V-, CD66-, BCRP1- and Hsp27-positive MP. To specify the role of these MP subpopulations in breast cancer progression, further studies enrolling larger patient groups are part of ongoing research.
Item Description:Gesehen am 14.03.2023
Physical Description:Online Resource
ISSN:1791-7530

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