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Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes

Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeostasis and...

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Main Authors: Qiu, Ruiyue (Author) , Alikhanyan, Kristina (Author) , Volk, Nadine (Author) , Marques, Oriana (Author) , Mertens, Christina (Author) , Ruban Agarvas, Anand (Author) , Singh, Sanjana (Author) , Pepperkok, Rainer (Author) , Altamura, Sandro (Author) , Muckenthaler, Martina (Author)
Format: Article (Journal)
Language:English
Published: 24 November 2022
In: Molecular metabolism
Year: 2022, Volume: 66, Pages: 1-13
ISSN:2212-8778
DOI:10.1016/j.molmet.2022.101644
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmet.2022.101644
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2212877822002137
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Author Notes:Ruiyue Qiu, Kristina Alikhanyan, Nadine Volk, Oriana Marques, Christina Mertens, Anand Ruban Agarvas, Sanjana Singh, Rainer Pepperkok, Sandro Altamura, Martina U. Muckenthaler
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Summary:Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeostasis and is a central organ for T2DM. Here, we investigate how the control of iron metabolism in hepatocytes is affected by T2DM.
Item Description:Gesehen am 15.11.2023
Physical Description:Online Resource
ISSN:2212-8778
DOI:10.1016/j.molmet.2022.101644

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