Buchumschlag

Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes

Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeostasis and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Qiu, Ruiyue (VerfasserIn) , Alikhanyan, Kristina (VerfasserIn) , Volk, Nadine (VerfasserIn) , Marques, Oriana (VerfasserIn) , Mertens, Christina (VerfasserIn) , Ruban Agarvas, Anand (VerfasserIn) , Singh, Sanjana (VerfasserIn) , Pepperkok, Rainer (VerfasserIn) , Altamura, Sandro (VerfasserIn) , Muckenthaler, Martina (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 24 November 2022
In: Molecular metabolism
Year: 2022, Jahrgang: 66, Pages: 1-13
ISSN:2212-8778
DOI:10.1016/j.molmet.2022.101644
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmet.2022.101644
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2212877822002137
Volltext
Verfasserangaben:Ruiyue Qiu, Kristina Alikhanyan, Nadine Volk, Oriana Marques, Christina Mertens, Anand Ruban Agarvas, Sanjana Singh, Rainer Pepperkok, Sandro Altamura, Martina U. Muckenthaler
Beschreibung
Zusammenfassung:Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeostasis and is a central organ for T2DM. Here, we investigate how the control of iron metabolism in hepatocytes is affected by T2DM.
Beschreibung:Gesehen am 15.11.2023
Beschreibung:Online Resource
ISSN:2212-8778
DOI:10.1016/j.molmet.2022.101644

Ähnliche Einträge