Identification of potential interferents of methylmalonic acid: a previously unrecognized pitfall in clinical diagnostics and newborn screening

Determination of methylmalonic acid (MMA) from dried blood spots (DBS) is commonly performed in clinical diagnostics and newborn screening for propionic acidemia (PA) and methylmalonic acidemia. Isobaric compounds of MMA having the same mass can affect diagnostic reliability and quantitative results...

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Main Authors:	Monostori, Péter (Author) , Godejohann, Markus (Author) , Janda, Joachim (Author) , Galla, Zsolt (Author) , Rácz, Gábor (Author) , Klinke, Glynis (Author) , Szatmári, Ildikó (Author) , Zsidegh, Petra (Author) , Kohlmüller, Dirk (Author) , Kölker, Stefan (Author) , Hoffmann, Georg F. (Author) , Gramer, Gwendolyn (Author) , Okun, Jürgen G. (Author)
Format:	Article (Journal)
Language:	English
Published:	2023
In:	Clinical biochemistry Year: 2023, Volume: 111, Pages: 72-80
ISSN:	1873-2933
DOI:	10.1016/j.clinbiochem.2022.09.010
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clinbiochem.2022.09.010 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0009912022002247
Author Notes:	Péter Monostori, Markus Godejohann, Joachim Janda, Zsolt Galla, Gábor Rácz, Glynis Klinke, Ildikó Szatmári, Petra Zsidegh, Dirk Kohlmüller, Stefan Kölker, Georg F. Hoffmann, Gwendolyn Gramer, Jürgen G. Okun