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Impact of drug transporters on cellular resistance towards saquinavir and darunavir

Highly active antiretroviral therapy is complicated by drug-drug interactions and the development of viral resistance. Drug interactions involve transporters that may critically affect the pharmacokinetics of many antiretroviral drugs and contribute to the formation of functional sanctuary sites. We...

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Bibliographic Details
Main Authors: König, Sonja Katharina (Author) , Herzog, Melanie (Author) , Theile, Dirk (Author) , Zembruski, Nadine Cécile Luise (Author) , Haefeli, Walter E. (Author) , Weiß, Johanna (Author)
Format: Article (Journal)
Language:English
Published: 3 September 2010
In: The journal of antimicrobial chemotherapy
Year: 2010, Volume: 65, Issue: 11, Pages: 2319-2328
ISSN:1460-2091
DOI:10.1093/jac/dkq324
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/jac/dkq324
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/jac/article/65/11/2319/763783
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Author Notes:Sonja Katharina König, Melanie Herzog, Dirk Theile, Nadine Zembruski, Walter Emil Haefeli and Johanna Weiss
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Summary:Highly active antiretroviral therapy is complicated by drug-drug interactions and the development of viral resistance. Drug interactions involve transporters that may critically affect the pharmacokinetics of many antiretroviral drugs and contribute to the formation of functional sanctuary sites. We therefore investigated the effect of saquinavir and darunavir on drug transporter expression and functional consequences for cellular resistance towards these compounds.
Item Description:Gesehen am 16.03.2023
Physical Description:Online Resource
ISSN:1460-2091
DOI:10.1093/jac/dkq324

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