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Enantioselective one-pot rhodium-catalyzed cycloisomerization-Wittig sequence to chiral functionalized 4-alkyl 3-alkylidene tetrahydrofuran(on)es

Alkyl and (hetero)aryl alkyne allyl alcohols can readily be transformed into chiral 4-alkyl 3-alkylidene tetrahydrofurans and tetrahydrofuranones bearing α,β-unsaturated carbonyl side chains in a one-pot fashion via an enantioselective rhodium-catalyzed ­cycloisomerization-Wittig olefination sequenc...

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Bibliographic Details
Main Authors: Körber, Nadine (Author) , Rominger, Frank (Author) , Müller, Thomas J. J. (Author)
Format: Article (Journal)
Language:English
Published: 08. Februar 2010
In: Synlett
Year: 2010, Issue: 05, Pages: 782-786
ISSN:1437-2096
DOI:10.1055/s-0029-1219362
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1055/s-0029-1219362
Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0029-1219362
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Author Notes:Nadine Körber, Frank Rominger, Thomas J.J. Müller
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Summary:Alkyl and (hetero)aryl alkyne allyl alcohols can readily be transformed into chiral 4-alkyl 3-alkylidene tetrahydrofurans and tetrahydrofuranones bearing α,β-unsaturated carbonyl side chains in a one-pot fashion via an enantioselective rhodium-catalyzed ­cycloisomerization-Wittig olefination sequence in good yields (54-86%).
Item Description:Gesehen am 16.03.2023
Physical Description:Online Resource
ISSN:1437-2096
DOI:10.1055/s-0029-1219362

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