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Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma

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Radiation therapy was the original mainstay of treatment for patients who had early-stage Hodgkin's lymphoma with a favorable prognosis. With the use of such techniques as extended-field radiation therapy and total lymphoid irradiation, more than 80% of patients with localized disease became lo...

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Hauptverfasser: Engert, Andreas (VerfasserIn) , Plütschow, Annette (VerfasserIn) , Eich, Hans Theodor (VerfasserIn) , Lohri, Andreas (VerfasserIn) , Dörken, Bernd (VerfasserIn) , Borchmann, Peter (VerfasserIn) , Berger, Bernhard (VerfasserIn) , Greil, Richard (VerfasserIn) , Willborn, Kay C. (VerfasserIn) , Wilhelm, Martin (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Eble, Michael J. (VerfasserIn) , Sökler, Martin (VerfasserIn) , Ho, Anthony Dick (VerfasserIn) , Rank, Andreas (VerfasserIn) , Ganser, Arnold (VerfasserIn) , Trümper, Lorenz (VerfasserIn) , Bokemeyer, Carsten (VerfasserIn) , Kirchner, Hartmut (VerfasserIn) , Schubert, Jörg (VerfasserIn) , Král, Zdenek (VerfasserIn) , Fuchs, Michael (VerfasserIn) , Müller-Hermelink, Hans-Konrad (VerfasserIn) , Müller, Rolf-Peter (VerfasserIn) , Diehl, Volker (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 12, 2010
In: The New England journal of medicine
Year: 2010, Jahrgang: 363, Heft: 7, Pages: 640-652
ISSN:1533-4406
DOI:10.1056/NEJMoa1000067
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa1000067
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Verfasserangaben:Andreas Engert, Annette Plütschow, Hans Theodor Eich, Andreas Lohri, Bernd Dörken, Peter Borchmann, Bernhard Berger, Richard Greil, Kay C. Willborn, Martin Wilhelm, Jürgen Debus, Michael J. Eble, Martin Sökler, Antony Ho, Andreas Rank, Arnold Ganser, Lorenz Trümper, Carsten Bokemeyer, Hartmut Kirchner, Jörg Schubert, Zdenek Král, Michael Fuchs, Hans-Konrad Müller-Hermelink, Rolf-Peter Müller, and Volker Diehl
Beschreibung
Zusammenfassung:Radiation therapy was the original mainstay of treatment for patients who had early-stage Hodgkin's lymphoma with a favorable prognosis. With the use of such techniques as extended-field radiation therapy and total lymphoid irradiation, more than 80% of patients with localized disease became long-term survivors. However, the relapse rate with radiation therapy alone ranged from 20 to 40%,1-3 and extended-field radiation therapy and total lymphoid irradiation were associated with the occurrence of secondary solid tumors.4-8 The integration of a chemotherapy regimen consisting of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)9 with radiation therapy resulted in greater efficacy and allowed the . . .
Beschreibung:Gesehen am 16.03.2023
Beschreibung:Online Resource
ISSN:1533-4406
DOI:10.1056/NEJMoa1000067

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