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Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells

Human multipotent mesenchymal stromal cells (MSC) can be isolated from various tissues including bone marrow. Here, MSC participate as bone lining cells in the formation of the hematopoietic stem cell niche. In this compartment, the oxygen tension is low and oxygen partial pressure is estimated to r...

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Autori principali: Holzwarth, Christina (Autore) , Vaegler, Martin (Autore) , Gieseke, Friederike (Autore) , Pfister, Stefan (Autore) , Handgretinger, Rupert (Autore) , Kerst, Gunter (Autore) , Müller, Ingo (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 28 January 2010
In: BMC cell biology
Year: 2010, Volume: 11, Pages: 1-11
ISSN:1471-2121
DOI:10.1186/1471-2121-11-11
Accesso online:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2121-11-11
Testo
Note sull'autore:Christina Holzwarth, Martin Vaegler, Friederike Gieseke, Stefan M. Pfister, Rupert Handgretinger, Gunter Kerst, Ingo Müller
Descrizione
Riassunto:Human multipotent mesenchymal stromal cells (MSC) can be isolated from various tissues including bone marrow. Here, MSC participate as bone lining cells in the formation of the hematopoietic stem cell niche. In this compartment, the oxygen tension is low and oxygen partial pressure is estimated to range from 1% to 7%. We analyzed the effect of low oxygen tensions on human MSC cultured with platelet-lysate supplemented media and assessed proliferation, morphology, chromosomal stability, immunophenotype and plasticity.
Descrizione del documento:Gesehen am 17.03.2023
Descrizione fisica:Online Resource
ISSN:1471-2121
DOI:10.1186/1471-2121-11-11

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