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Trophoblast cell surface antigen 2 (Trop2) in chromophobe renal cell carcinoma

Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact o...

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Main Authors: Mikuteit, Marie (Author) , Steffens, Sandra (Author) , Zschäbitz, Stefanie (Author) , Autenrieth, Michael (Author) , Weichert, Wilko (Author) , Hartmann, Arndt (Author) , Erlmeier, Franziska (Author)
Format: Article (Journal)
Language:English
Published: February 15, 2022
In: Oncology
Year: 2022, Volume: 100, Issue: 6, Pages: 331-336
ISSN:1423-0232
DOI:10.1159/000522592
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000522592
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/522592
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Author Notes:Marie Mikuteit, Sandra Steffens, Stefanie Zschäbitz, Michael Autenrieth, Wilko Weichert, Arndt Hartmann, Franziska Erlmeier
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Summary:Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. Materials and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2− compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). Conclusion: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.
Item Description:Gesehen am 20.03.2023
Physical Description:Online Resource
ISSN:1423-0232
DOI:10.1159/000522592

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