Buchumschlag

Trophoblast cell surface antigen 2 (Trop2) in chromophobe renal cell carcinoma

Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact o...

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Hauptverfasser: Mikuteit, Marie (VerfasserIn) , Steffens, Sandra (VerfasserIn) , Zschäbitz, Stefanie (VerfasserIn) , Autenrieth, Michael (VerfasserIn) , Weichert, Wilko (VerfasserIn) , Hartmann, Arndt (VerfasserIn) , Erlmeier, Franziska (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February 15, 2022
In: Oncology
Year: 2022, Jahrgang: 100, Heft: 6, Pages: 331-336
ISSN:1423-0232
DOI:10.1159/000522592
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000522592
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/522592
Volltext
Verfasserangaben:Marie Mikuteit, Sandra Steffens, Stefanie Zschäbitz, Michael Autenrieth, Wilko Weichert, Arndt Hartmann, Franziska Erlmeier
Beschreibung
Zusammenfassung:Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. Materials and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2− compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). Conclusion: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.
Beschreibung:Gesehen am 20.03.2023
Beschreibung:Online Resource
ISSN:1423-0232
DOI:10.1159/000522592

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