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Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells

We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-β1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons. In the present study we have analyzed the mechanisms underlying these phenome...

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Main Authors: Koesters, Robert (Author) , Kaissling, Brigitte (Author) , LeHir, Michel (Author) , Picard, Nicolas (Author) , Theilig, Franziska (Author) , Gebhardt, Rolf (Author) , Glick, Adam B. (Author) , Hähnel, Brunhilde (Author) , Hosser, Hiltraud (Author) , Gröne, Hermann-Josef (Author) , Kriz, Wilhelm (Author)
Format: Article (Journal)
Language:English
Published: 16 December 2010
In: The American journal of pathology
Year: 2010, Volume: 177, Issue: 2, Pages: 632-643
ISSN:1525-2191
DOI:10.2353/ajpath.2010.091012
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.2353/ajpath.2010.091012
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0002944010601216
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Author Notes:Robert Koesters, Brigitte Kaissling, Michel LeHir, Nicolas Picard, Franziska Theilig, Rolf Gebhardt, Adam B. Glick, Brunhilde Hähnel, Hiltraud Hosser, Hermann-Josef Gröne, and Wilhelm Kriz
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Summary:We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-β1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons. In the present study we have analyzed the mechanisms underlying these phenomena.
Item Description:Gesehen am 21.03.2023
Physical Description:Online Resource
ISSN:1525-2191
DOI:10.2353/ajpath.2010.091012

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