Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-β1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons. In the present study we have analyzed the mechanisms underlying these phenome...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 December 2010
|
| In: |
The American journal of pathology
Year: 2010, Volume: 177, Issue: 2, Pages: 632-643 |
| ISSN: | 1525-2191 |
| DOI: | 10.2353/ajpath.2010.091012 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.2353/ajpath.2010.091012 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0002944010601216 
|
| Author Notes: | Robert Koesters, Brigitte Kaissling, Michel LeHir, Nicolas Picard, Franziska Theilig, Rolf Gebhardt, Adam B. Glick, Brunhilde Hähnel, Hiltraud Hosser, Hermann-Josef Gröne, and Wilhelm Kriz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1839639539 | ||
| 003 | DE-627 | ||
| 005 | 20251020134134.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230321s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2353/ajpath.2010.091012 |2 doi | |
| 035 | |a (DE-627)1839639539 | ||
| 035 | |a (DE-599)KXP1839639539 | ||
| 035 | |a (OCoLC)1389807316 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Koesters, Robert |e VerfasserIn |0 (DE-588)1076838081 |0 (DE-627)835382222 |0 (DE-576)17111342X |4 aut | |
| 245 | 1 | 0 | |a Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells |c Robert Koesters, Brigitte Kaissling, Michel LeHir, Nicolas Picard, Franziska Theilig, Rolf Gebhardt, Adam B. Glick, Brunhilde Hähnel, Hiltraud Hosser, Hermann-Josef Gröne, and Wilhelm Kriz |
| 246 | 3 | 0 | |a factor - β1 β 1 beta beta1 |
| 246 | 3 | 3 | |a Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells |
| 264 | 1 | |c 16 December 2010 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.03.2023 | ||
| 520 | |a We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-β1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons. In the present study we have analyzed the mechanisms underlying these phenomena. | ||
| 700 | 1 | |a Kaissling, Brigitte |e VerfasserIn |4 aut | |
| 700 | 1 | |a LeHir, Michel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Picard, Nicolas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Theilig, Franziska |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gebhardt, Rolf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Glick, Adam B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hähnel, Brunhilde |d 1955- |e VerfasserIn |0 (DE-588)1139649353 |0 (DE-627)89736998X |0 (DE-576)49335784X |4 aut | |
| 700 | 1 | |a Hosser, Hiltraud |d 1949- |e VerfasserIn |0 (DE-588)1139649256 |0 (DE-627)897369807 |0 (DE-576)493357696 |4 aut | |
| 700 | 1 | |a Gröne, Hermann-Josef |d 1950- |e VerfasserIn |0 (DE-588)1054822697 |0 (DE-627)792339541 |0 (DE-576)170213773 |4 aut | |
| 700 | 1 | |a Kriz, Wilhelm |d 1936- |e VerfasserIn |0 (DE-588)172197570 |0 (DE-627)69711130X |0 (DE-576)133067750 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The American journal of pathology |d New York [u.a.] : Elsevier, 1925 |g 177(2010), 2 vom: Aug., Seite 632-643 |h Online-Ressource |w (DE-627)271352906 |w (DE-600)1480207-7 |w (DE-576)078591732 |x 1525-2191 |7 nnas |a Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells |
| 773 | 1 | 8 | |g volume:177 |g year:2010 |g number:2 |g month:08 |g pages:632-643 |g extent:12 |a Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells |
| 856 | 4 | 0 | |u https://doi.org/10.2353/ajpath.2010.091012 |x Resolving-System |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0002944010601216 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230321 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 172197570 |a Kriz, Wilhelm |m 172197570:Kriz, Wilhelm |d 50000 |d 53100 |e 50000PK172197570 |e 53100PK172197570 |k 0/50000/ |k 1/50000/53100/ |p 11 |y j | ||
| 998 | |g 1054822697 |a Gröne, Hermann-Josef |m 1054822697:Gröne, Hermann-Josef |d 50000 |e 50000PG1054822697 |k 0/50000/ |p 10 | ||
| 998 | |g 1139649256 |a Hosser, Hiltraud |m 1139649256:Hosser, Hiltraud |d 50000 |d 53100 |e 50000PH1139649256 |e 53100PH1139649256 |k 0/50000/ |k 1/50000/53100/ |p 9 | ||
| 998 | |g 1139649353 |a Hähnel, Brunhilde |m 1139649353:Hähnel, Brunhilde |d 50000 |d 53100 |e 50000PH1139649353 |e 53100PH1139649353 |k 0/50000/ |k 1/50000/53100/ |p 8 | ||
| 998 | |g 1076838081 |a Koesters, Robert |m 1076838081:Koesters, Robert |p 1 |x j | ||
| 999 | |a KXP-PPN1839639539 |e 4293959246 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"disp":"Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cellsThe American journal of pathology","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1925 -"],"title":[{"title":"The American journal of pathology","title_sort":"American journal of pathology","subtitle":"cellular and molecular biology of disease ; official publication of the American Society for Investigative Pathology"}],"origin":[{"publisherPlace":"New York [u.a.] ; Bethesda, Md.","publisher":"Elsevier ; American Society for Investigative Pathology","dateIssuedKey":"1925","dateIssuedDisp":"1925-"}],"part":{"volume":"177","pages":"632-643","text":"177(2010), 2 vom: Aug., Seite 632-643","issue":"2","year":"2010","extent":"12"},"id":{"zdb":["1480207-7"],"eki":["271352906"],"issn":["1525-2191"]},"language":["eng"],"recId":"271352906","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 19.02.2024"]}],"id":{"doi":["10.2353/ajpath.2010.091012"],"eki":["1839639539"]},"origin":[{"dateIssuedDisp":"16 December 2010","dateIssuedKey":"2010"}],"note":["Gesehen am 21.03.2023"],"person":[{"display":"Koesters, Robert","role":"aut","roleDisplay":"VerfasserIn","given":"Robert","family":"Koesters"},{"given":"Brigitte","family":"Kaissling","display":"Kaissling, Brigitte","role":"aut","roleDisplay":"VerfasserIn"},{"family":"LeHir","given":"Michel","role":"aut","roleDisplay":"VerfasserIn","display":"LeHir, Michel"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Picard, Nicolas","family":"Picard","given":"Nicolas"},{"display":"Theilig, Franziska","role":"aut","roleDisplay":"VerfasserIn","family":"Theilig","given":"Franziska"},{"family":"Gebhardt","given":"Rolf","role":"aut","roleDisplay":"VerfasserIn","display":"Gebhardt, Rolf"},{"display":"Glick, Adam B.","roleDisplay":"VerfasserIn","role":"aut","given":"Adam B.","family":"Glick"},{"given":"Brunhilde","family":"Hähnel","display":"Hähnel, Brunhilde","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Hiltraud","family":"Hosser","roleDisplay":"VerfasserIn","role":"aut","display":"Hosser, Hiltraud"},{"given":"Hermann-Josef","family":"Gröne","display":"Gröne, Hermann-Josef","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kriz, Wilhelm","given":"Wilhelm","family":"Kriz"}],"physDesc":[{"extent":"12 S."}],"recId":"1839639539","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"titleAlt":[{"title":"Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells"}],"name":{"displayForm":["Robert Koesters, Brigitte Kaissling, Michel LeHir, Nicolas Picard, Franziska Theilig, Rolf Gebhardt, Adam B. Glick, Brunhilde Hähnel, Hiltraud Hosser, Hermann-Josef Gröne, and Wilhelm Kriz"]},"title":[{"title_sort":"Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells","title":"Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells"}]} | ||
| SRT | |a KOESTERSROTUBULAROVE1620 | ||