An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line
The eukaryotic transcription factor nuclear factor-κB (NF-κB) is mainly involved in the regulation of immune response and inflammation. A prolonged activation of NF-κB has been reported in context with chronic diseases. What leads to a prolongation of NF-κB activity is not well understood. Here, an...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 September 2010
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| In: |
Virchows Archiv
Year: 2010, Volume: 457, Issue: 5, Pages: 585-595 |
| ISSN: | 1432-2307 |
| DOI: | 10.1007/s00428-010-0970-0 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-010-0970-0 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00428-010-0970-0 
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| Author Notes: | Patricia Kohlhof |
| Summary: | The eukaryotic transcription factor nuclear factor-κB (NF-κB) is mainly involved in the regulation of immune response and inflammation. A prolonged activation of NF-κB has been reported in context with chronic diseases. What leads to a prolongation of NF-κB activity is not well understood. Here, an increase in total intracellular NF-κB protein and mRNA levels as well as a temporary colocalization of NF-κB with proteasomes in human hepatocytes after treatment with TNF-α or IL-1β is reported. This indicates that beside an instantaneous activation of NF-κB and partly autoregulated inactivation by breakdown and synthesis of the inhibitors of NF-κB (IκBs), there are also mechanisms for a long-term regulation by de novo-synthesis and degradation of NF-κB protein. |
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| Item Description: | Gesehen am 21.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1432-2307 |
| DOI: | 10.1007/s00428-010-0970-0 |