Cell-cycle regulation in embryonic stem cells: centrosomal decisions on self-renewal
Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle r...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 Jul 2010
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| In: |
Stem Cells and Development
Year: 2010, Jahrgang: 19, Heft: 11, Pages: 1663-1678 |
| ISSN: | 1557-8534 |
| DOI: | 10.1089/scd.2010.0136 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1089/scd.2010.0136 Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/scd.2010.0136 
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| Verfasserangaben: | Zuzana Koledova, Alwin Krämer, Leona Raskova Kafkova, Vladimir Divoky |
| Zusammenfassung: | Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette. |
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| Beschreibung: | Gesehen am 21.03.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1557-8534 |
| DOI: | 10.1089/scd.2010.0136 |