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Cell-cycle regulation in embryonic stem cells: centrosomal decisions on self-renewal

Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle r...

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Bibliographic Details
Main Authors: Sumbalova Koledova, Zuzana (Author) , Krämer, Alwin (Author) , Kafkova, Leona Raskova (Author) , Divoky, Vladimir (Author)
Format: Article (Journal)
Language:English
Published: 1 Jul 2010
In: Stem Cells and Development
Year: 2010, Volume: 19, Issue: 11, Pages: 1663-1678
ISSN:1557-8534
DOI:10.1089/scd.2010.0136
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1089/scd.2010.0136
Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/scd.2010.0136
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Author Notes:Zuzana Koledova, Alwin Krämer, Leona Raskova Kafkova, Vladimir Divoky
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Summary:Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette.
Item Description:Gesehen am 21.03.2023
Physical Description:Online Resource
ISSN:1557-8534
DOI:10.1089/scd.2010.0136

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