The dual nature of the nucleolus
The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022
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| In: |
Genes & development
Year: 2022, Volume: 36, Issue: 13-14, Pages: 765-769 |
| ISSN: | 1549-5477 |
| DOI: | 10.1101/gad.349748.122 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1101/gad.349748.122 Verlag, lizenzpflichtig, Volltext: http://genesdev.cshlp.org/content/36/13-14/765 
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| Author Notes: | Alan Tartakoff, Patrick DiMario, Eduard Hurt, Brian McStay, Vikram Govind Panse, and David Tollervey |
| Summary: | The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors. |
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| Item Description: | Gesehen am 21.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1549-5477 |
| DOI: | 10.1101/gad.349748.122 |