Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

Medulloblastoma (MB) is the most common malignant brain tumor in children, whereas it rarely presents in adults. We aimed to identify genetic aberrations in 146 adult MBs to evaluate age-dependent differences in tumor biology and adapt age-specific risk stratification models.

Bibliographic Details

Main Authors:	Korshunov, Andrey (Author) , Remke, Marc (Author) , Werft, Wiebke (Author) , Benner, Axel (Author) , Ryzhova, Marina (Author) , Witt, Hendrik (Author) , Sturm, Dominik (Author) , Wittmann, Andrea (Author) , Schöttler, Anna (Author) , Felsberg, Jörg (Author) , Reifenberger, Guido (Author) , Rutkowski, Stefan (Author) , Scheurlen, Wolfram (Author) , Kulozik, Andreas (Author) , Deimling, Andreas von (Author) , Lichter, Peter (Author) , Pfister, Stefan (Author)
Format:	Article (Journal)
Language:	English
Published:	May 17, 2010
In:	Journal of clinical oncology Year: 2010, Volume: 28, Issue: 18, Pages: 3054-3060
ISSN:	1527-7755
DOI:	10.1200/JCO.2009.25.7121
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1200/JCO.2009.25.7121 Verlag, lizenzpflichtig, Volltext: https://ascopubs.org/doi/10.1200/JCO.2009.25.7121
Author Notes:	Andrey Korshunov, Marc Remke, Wiebke Werft, Axel Benner, Marina Ryzhova, Hendrik Witt, Dominik Sturm, Andrea Wittmann, Anna Schöttler, Jörg Felsberg, Guido Reifenberger, Stefan Rutkowski, Wolfram Scheurlen, Andreas E. Kulozik, Andreas von Deimling, Peter Lichter, and Stefan M. Pfister