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Air pollution exposure increases ABCB1 and ASCT1 transporter levels in mouse cortex

Membrane transporters are important for maintaining brain homeostasis by regulating the passage of solutes into, out of, and within the brain. Growing evidence suggests neurotoxic effects of air pollution exposure and its contribution to neurodegenerative disorders, including Alzheimer’s disease (AD...

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Main Authors: Puris, Elena (Author) , Saveleva, Liudmila (Author) , Górová, Veronika (Author) , Vartiainen, Petra (Author) , Kortelainen, Miika (Author) , Lamberg, Heikki (Author) , Sippula, Olli (Author) , Malm, Tarja (Author) , Jalava, Pasi I. (Author) , Auriola, Seppo (Author) , Fricker, Gert (Author) , Kanninen, Katja M. (Author)
Format: Article (Journal)
Language:English
Published: 27 October 2022
In: Environmental toxicology and pharmacology
Year: 2022, Volume: 96, Pages: 1-9
ISSN:1872-7077
DOI:10.1016/j.etap.2022.104003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.etap.2022.104003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S138266892200196X
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Author Notes:Elena Puris, Liudmila Saveleva, Veronika Górová, Petra Vartiainen, Miika Kortelainen, Heikki Lamberg, Olli Sippula, Tarja Malm, Pasi I. Jalava, Seppo Auriola, Gert Fricker, Katja M. Kanninen
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Summary:Membrane transporters are important for maintaining brain homeostasis by regulating the passage of solutes into, out of, and within the brain. Growing evidence suggests neurotoxic effects of air pollution exposure and its contribution to neurodegenerative disorders, including Alzheimer’s disease (AD), yet limited knowledge is available on the exact cellular impacts of exposure. This study investigates how exposure to ubiquitous solid components of air pollution, ultrafine particles (UFPs), influence brain homeostasis by affecting protein levels of membrane transporters. Membrane transporters were quantified and compared in brain cortical samples of wild-type and the 5xFAD mouse model of AD in response to subacute exposure to inhaled UFPs. The cortical ASCT1 and ABCB1 transporter levels were elevated in wild-type and 5xFAD mice subjected to a 2-week UFP exposure paradigm, suggesting impairment of brain homeostatic mechanisms. This study provides new insight on the molecular mechanisms underlying adverse effects of air pollution on the brain.
Item Description:Online verfügbar 22 October 2022, Version des Artikels 27 October 2022
Gesehen am 27.03.2023
Physical Description:Online Resource
ISSN:1872-7077
DOI:10.1016/j.etap.2022.104003

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