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Controversies in the management of patients with soft tissue sarcoma: recommendations of the Conference on State of Science in Sarcoma 2022

Background - Owing to the rarity and heterogeneity in biology and presentation, there are multiple areas in the diagnosis, treatment and follow-up of soft tissue sarcoma (STS), with no, low-level or conflicting evidence. - Methods - During the first Consensus Conference on the State of Science in Sa...

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Main Authors: Rothermundt, Christian (Author) , Andreou, Dimosthenis (Author) , Blay, Jean-Yves (Author) , Brodowicz, Thomas (Author) , Desar, Ingrid M. E. (Author) , Dileo, Palma (Author) , Gelderblom, Hans (Author) , Haas, Rick (Author) , Jakob, Jens (Author) , Jones, Robin L. (Author) , Judson, Ian (Author) , Kunz, Wolfgang G. (Author) , Liegl-Atzwanger, Berndadette (Author) , Lindner, Lars H. (Author) , Messiou, Christina (Author) , Miah, Aisha B. (Author) , Reichardt, Peter (Author) , Szkandera, Joanna (Author) , Graaf, Wilhelmina Tita Alide van der (Author) , van Houdt, Winan J. (Author) , Wardelmann, Eva (Author) , Hofer, Silvia (Author) , Barth, Thomas (Author) , Bauer, Sebastian (Author) , Blum, Veronika (Author) , Bode, Beata (Author) , Bonvalot, Sylvie (Author) , Bovee, Judith (Author) , Braam, Petra (Author) , Broto, Jean Martin (Author) , Dei Tos, Angelo (Author) , Denschlag, Dominik (Author) , Desar, Ingrid (Author) , Digklia, Antonia (Author) , Dirksen, Uta (Author) , Douchy, Thomas (Author) , Duffaud, Florence (Author) , Eriksson, Mikael (Author) , Fröhling, Stefan (Author) , Gronchi, Alessandro (Author) , Hardes, Jenrik (Author) , Hartmann, Wolfgang (Author) , Hohenberger, Peter (Author) , Mechtersheimer, Gunhild (Author) , Köhler, Günter (Author) , Lindner, Lars (Author) , Pink, Daniel (Author) , Tunn, Per-Ulf (Author)
Format: Article (Journal) Conference Paper
Language:English
Published: 2 January 2023
In: European journal of cancer
Year: 2023, Volume: 180, Pages: 158-179
ISSN:1879-0852
DOI:10.1016/j.ejca.2022.11.008
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejca.2022.11.008
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0959804922013442
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Author Notes:Christian Rothermundt, Dimosthenis Andreou, Jean-Yves Blay, Thomas Brodowicz, Ingrid M. E. Desar, Palma Dileo, Hans Gelderblom, Rick Haas, Jens Jakob, Robin L. Jones, Ian Judson, Wolfgang G. Kunz, Berndadette Liegl-Atzwanger, Lars H. Lindner, Christina Messiou, Aisha B. Miah, Peter Reichardt, Joanna Szkandera, Winette T.A. van der Graaf, Winan J. van Houdt, Eva Wardelmann, Silvia Hofer, Dimosthenis Andreou, Thomas Barth, Sebastian Bauer, Jean-Yves Blay, Veronika Blum, Beata Bode, Sylvie Bonvalot, Judith Bovee, Petra Braam, Thomas Brodowicz, Jean Martin Broto, Angelo Dei Tos, Dominik Denschlag, Ingrid Desar, Antonia Digklia, Palma Dileo, Uta Dirksen, Thomas Douchy, Florence Duffaud, Mikael Eriksson, Stefan Fröhling, Hans Gelderblom, Alessandro Gronchi, Rick Haas, Jenrik Hardes, Wolfgang Hartmann, Silvia Hofer ; writing committee on behalf of CSSS panellists
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Summary:Background - Owing to the rarity and heterogeneity in biology and presentation, there are multiple areas in the diagnosis, treatment and follow-up of soft tissue sarcoma (STS), with no, low-level or conflicting evidence. - Methods - During the first Consensus Conference on the State of Science in Sarcoma (CSSS), we used a modified Delphi process to identify areas of controversy in the field of sarcoma, to name topics with limited evidence-based data in which a scientific and knowledge gap may remain and a consensus statement will help to guide patient management. We determined scientific questions which need to be addressed in the future in order to generate evidence and to inform physicians and caregivers in daily clinical practice in order to improve the outcomes of patients with sarcoma. We conducted a vote on STS key questions and controversies prior to the CSSS meeting, which took place in May 2022. - Results - Sixty-two European sarcoma experts participated in the survey. Sixteen strong consensus (≥95%) items were identified by the experts, as well as 30 items with a ≥75% consensus on diagnostic and therapeutic questions. Ultimately, many controversy topics remained without consensus. - Conclusions - In this manuscript, we summarise the voting results and the discussion during the CSSS meeting. Future scientific questions, priorities for clinical trials, registries, quality assurance, and action by stakeholders are proposed. Platforms and partnerships can support innovative approaches to improve management and clinical research in STS.
Item Description:Appendix 1. CSSS panellists by country and speciality: Andreaou, Dimosthenis [und viele weitere]
Online verfügbar: 16. November 2022, Artikelversion: 2. Januar 2023
Gesehen am 28.03.2023
Physical Description:Online Resource
ISSN:1879-0852
DOI:10.1016/j.ejca.2022.11.008

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