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Association of tumor volumetry with postoperative outcomes for cervical paraganglioma

Objectives: To analyze the association of tumor volume with outcome after surgery for cervical paraganglioma. Materials and Methods: This retrospective study included consecutive patients undergoing surgery for cervical paraganglioma from 2009-2020. Outcomes were 30-day morbidity, mortality, cranial...

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Main Authors: Hoffmann-Wieker, Carola Marie (Author) , Gomes dos Santos Ferreira Rebelo, Artur Luis (Author) , Moll, Martin (Author) , Ronellenfitsch, Ulrich (Author) , Rengier, Fabian (Author) , Erhart, Philipp (Author) , Böckler, Dittmar (Author) , Ukkat, Jörg (Author)
Format: Article (Journal)
Language:English
Published: 15 February 2023
In: Diagnostics
Year: 2023, Volume: 13, Issue: 4, Pages: 1-9
ISSN:2075-4418
DOI:10.3390/diagnostics13040744
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/diagnostics13040744
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4418/13/4/744
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Author Notes:Carola Marie Hoffmann-Wieker, Artur Rebelo, Martin Moll, Ulrich Ronellenfitsch, Fabian Rengier, Philipp Erhart, Dittmar Böckler and Jörg Ukkat
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Summary:Objectives: To analyze the association of tumor volume with outcome after surgery for cervical paraganglioma. Materials and Methods: This retrospective study included consecutive patients undergoing surgery for cervical paraganglioma from 2009-2020. Outcomes were 30-day morbidity, mortality, cranial nerve injury, and stroke. Preoperative CT/MRI was used for tumor volumetry. An association between the volume and the outcomes was explored in univariate and multivariable analyses. A receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was calculated. The study was conducted and reported according to the STROBE statement. Results: Volumetry was successful in 37/47 (78.8%) of included patients. A 30-day morbidity occurred in 13/47 (27.6%) patients with no mortality. Fifteen cranial nerve lesions occurred in eleven patients. The mean tumor volume was 6.92 cm3 in patients without and 15.89 cm3 in patients with complications (p = 0.035) and 7.64 cm3 in patients without and 16.28 cm3 in patients with cranial nerve injury (p = 0.05). Neither the volume nor Shamblin grade was significantly associated with complications on multivariable analysis. The AUC was 0.691, indicating a poor to fair performance of volumetry in predicting postoperative complications. Conclusions: Surgery for cervical paraganglioma bears a relevant morbidity with a particular risk of cranial nerve lesions. Tumor volume is associated with morbidity, and MRI/CT volumetry can be used for risk stratification.
Item Description:Gesehen am 28.03.2023
Physical Description:Online Resource
ISSN:2075-4418
DOI:10.3390/diagnostics13040744

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