Generation of three induced pluripotent stem cell lines carrying different variants of the BDNF (Val66Met) polymorphism
Brain-derived neurotrophic factor (BDNF) has been implicated in a multitude of neurodevelopmental processes including neuronal differentiation, axonal outgrowth, synaptic plasticity, or survival. One human-specific single nucleotide polymorphism (rs6265) in the BDNF gene causes a substitution of val...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2023
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| In: |
Stem cell research
Year: 2023, Volume: 66, Pages: 1-4 |
| ISSN: | 1876-7753 |
| DOI: | 10.1016/j.scr.2022.102989 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.scr.2022.102989 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1873506122003385 
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| Author Notes: | Sandra Horschitz, Josef Frank, Philipp Koch |
| Summary: | Brain-derived neurotrophic factor (BDNF) has been implicated in a multitude of neurodevelopmental processes including neuronal differentiation, axonal outgrowth, synaptic plasticity, or survival. One human-specific single nucleotide polymorphism (rs6265) in the BDNF gene causes a substitution of valine (Val) to methionine (Met) at codon 66 in the pro domain of the protein (Val66Met). This substitution is associated to reduced hippocampal volumes, poor performance on hippocampal-dependent memory tasks, and some mental disorders such as schizophrenia, depression or Alzheimer’s disease. Here we generated three iPSC lines from healthy donors, either homozygous (Val/Val and Met/Met) or heterozygous (Val/Met) for the polymorphism. |
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| Item Description: | Online verfügbar 5 Dezember 2022 Gesehen am 28.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1876-7753 |
| DOI: | 10.1016/j.scr.2022.102989 |