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β2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells

Hypoxia impairs alveolar fluid clearance by inhibition of Na+ reabsorption, and also impairs β2 adrenergic signaling in alveolar epithelium. Since both are major rescue mechanisms preventing pulmonary edema, we studied whether acute and prolonged treatment with terbutaline would prevent hypoxic inhi...

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Bibliographic Details
Main Authors: Löh, Benjamin (Author) , Baloglu, Emel (Author) , Ke, Alberto (Author) , Bärtsch, Peter (Author) , Mairbäurl, Heimo (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Cellular physiology and biochemistry
Year: 2010, Volume: 25, Issue: 1, Pages: 123-134
ISSN:1421-9778
DOI:10.1159/000272057
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1159/000272057
Verlag, kostenfrei, Volltext: https://www.karger.com/Article/FullText/272057
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Author Notes:Benjamin Loeh, Emel Baloglu, Alberto Ke, Peter Bärtsch and Heimo Mairbäurl
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Summary:Hypoxia impairs alveolar fluid clearance by inhibition of Na+ reabsorption, and also impairs β2 adrenergic signaling in alveolar epithelium. Since both are major rescue mechanisms preventing pulmonary edema, we studied whether acute and prolonged treatment with terbutaline would prevent hypoxic inhibition of ion transport.
Item Description:Online veröffentlicht am 22. Dezember 2009
Gesehen am 29.03.2023
Physical Description:Online Resource
ISSN:1421-9778
DOI:10.1159/000272057

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