Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans
The clinical course and outcome of many diseases differ between women and men, with women experiencing a higher prevalence and more severe pathogenesis of autoimmune diseases. The precise mechanisms underlying these sex differences still remain to be fully understood. IRF5 is a master transcription...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 February 2023
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| In: |
Biology of sex differences
Year: 2023, Volume: 14, Pages: 1-11 |
| ISSN: | 2042-6410 |
| DOI: | 10.1186/s13293-023-00495-x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13293-023-00495-x
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| Author Notes: | Claudia Beisel, Ana Jordan-Paiz, Sandra Köllmann, Annika Elise Ahrenstorf, Benedetta Padoan, Tanja Barkhausen, Marylyn M. Addo and Marcus Altfeld |
| Summary: | The clinical course and outcome of many diseases differ between women and men, with women experiencing a higher prevalence and more severe pathogenesis of autoimmune diseases. The precise mechanisms underlying these sex differences still remain to be fully understood. IRF5 is a master transcription factor that regulates TLR/MyD88-mediated responses to pathogen-associated molecular patterns (PAMPS) in DCs and B cells. B cells are central effector cells involved in autoimmune diseases via the production of antibodies and pro-inflammatory cytokines as well as mediating T cell help. Dysregulation of IRF5 expression has been reported in autoimmune diseases, including systemic lupus erythematosus, primary Sjögren syndrome, and rheumatoid arthritis. |
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| Item Description: | Gesehen am 29.03.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2042-6410 |
| DOI: | 10.1186/s13293-023-00495-x |