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Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells

Tissue fibrosis is an integral component of chronic inflammatory (liver and pancreas) diseases and pancreatic cancer. Activated pancreatic- (PSC) and hepatic- (HSC) stellate cells play a key role in fibrogenesis. To identify organ- and disease-specific stellate cell transcriptional fingerprints, we...

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Main Authors: Erkan, Murat Mert (Author) , Weis, Nadine (Author) , Pan, Zheng (Author) , Schwager, Christian (Author) , Samkharadze, Tamar (Author) , Jiang, Xiaohua (Author) , Wirkner, Ute (Author) , Giese, Nathalia (Author) , Ansorge, Wilhelm (Author) , Debus, Jürgen (Author) , Huber, Peter E. (Author) , Friess, Helmut (Author) , Abdollahi, Amir (Author) , Kleeff, Jörg H. (Author)
Format: Article (Journal)
Language:English
Published: 23 April 2010
In: Molecular cancer
Year: 2010, Volume: 9, Pages: 1-15
ISSN:1476-4598
DOI:10.1186/1476-4598-9-88
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1476-4598-9-88
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Author Notes:Mert Erkan, Nadine Weis, Zheng Pan, Christian Schwager, Tamar Samkharadze, Xiaohua Jiang, Ute Wirkner, Nathalia A. Giese, Wilhelm Ansorge, Jürgen Debus, Peter E. Huber, Helmut Friess, Amir Abdollahi and Jörg Kleeff
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Summary:Tissue fibrosis is an integral component of chronic inflammatory (liver and pancreas) diseases and pancreatic cancer. Activated pancreatic- (PSC) and hepatic- (HSC) stellate cells play a key role in fibrogenesis. To identify organ- and disease-specific stellate cell transcriptional fingerprints, we employed genome-wide transcriptional analysis of primary human PSC and HSC isolated from patients with chronic inflammation or cancer.
Item Description:Gesehen am 03.04.2023
Physical Description:Online Resource
ISSN:1476-4598
DOI:10.1186/1476-4598-9-88

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