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Repeated low-dose computed tomography in current and former smokers for quantification of emphysema

Objective: - To quantify different emphysema evolution in current and former smokers. - Methods: - We retrospectively analyzed low-dose computed tomography scans from a lung cancer screening study of 59 current and 75 former smokers. The quantitative emphysema analysi...

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Bibliographische Detailangaben
Hauptverfasser: McGregor, Alexander (VerfasserIn) , Roberts, Heidi C. (VerfasserIn) , Dong, Zhi (VerfasserIn) , Menezes, Ravi (VerfasserIn) , Kauczor, Hans-Ulrich (VerfasserIn) , Weinheimer, Oliver (VerfasserIn) , Heußel, Claus Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2010
In: Journal of computer assisted tomography
Year: 2010, Jahrgang: 34, Heft: 6, Pages: 933-938
ISSN:1532-3145
DOI:10.1097/RCT.0b013e3181ef9fbe
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/RCT.0b013e3181ef9fbe
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/jcat/Fulltext/2010/11000/Repeated_Low_Dose_Computed_Tomography_in_Current.21.aspx
Volltext
Verfasserangaben:Alexander McGregor, Heidi C. Roberts, MD, Zhi Dong, MD, Ravi Menezes, PhD, Hans-Ulrich Kauczor, MD, Oliver Weinheimer, MD, and Claus Peter Heussel, MD
Beschreibung
Zusammenfassung:Objective: - To quantify different emphysema evolution in current and former smokers. - Methods: - We retrospectively analyzed low-dose computed tomography scans from a lung cancer screening study of 59 current and 75 former smokers. The quantitative emphysema analysis was performed using a home-built software (YACTA version 0.9), yielding the parameters lung volume, emphysema volume (EV), emphysema index (EI), mean lung density, and 15th percentile. - Results: - The baseline EV and EI were significantly different (median EVformer =422 mL vs EVcurrent =249 mL, P = 0.0003; and median EIformer =7.6 % vs EIcurrent =4.1 %, P = 0.0001, respectively). On the annual repeat scan, the median EI and EV for former smokers had decreased significantly (ΔEIformer = −0.257%, P = 0.004; and ΔEVcurrent = −0.203 mL, P = 0.020), whereas there was no emphysema change in current smokers. - Conclusions: - We were able to demonstrate different emphysema evolution in current versus former smokers; emphysema parameters decreased in the former smokers and remained stable in current smokers.
Beschreibung:Gesehen am 12.04.2023
Beschreibung:Online Resource
ISSN:1532-3145
DOI:10.1097/RCT.0b013e3181ef9fbe

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