Impact of chewing bags, e-cigarettes, and combustible cigarettes on arterial stiffness and small airway function in healthy students
Several substitute products are discussed as a healthier alternative to smoking, thereunder e-cigarettes and smokeless tobacco products, e.g., chewing bags, which are increasingly used in this context. We investigated the acute effects of chewing bags compared to combustible cigarettes and e-cigaret...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 January 2023
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| In: |
Toxics
Year: 2023, Volume: 11, Issue: 1, Pages: 1-12 |
| ISSN: | 2305-6304 |
| DOI: | 10.3390/toxics11010077 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/toxics11010077 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2305-6304/11/1/77 
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| Author Notes: | Annabelle Susann Hauck, Isabel Buchwald, Henrik Watz, Frederik Trinkmann, Charlotte Söling, Andrea Rabenstein, Tobias Ruether, Kai Mortensen, Daniel Drömann and Klaas Frederik Franzen |
| Summary: | Several substitute products are discussed as a healthier alternative to smoking, thereunder e-cigarettes and smokeless tobacco products, e.g., chewing bags, which are increasingly used in this context. We investigated the acute effects of chewing bags compared to combustible cigarettes and e-cigarettes with and without nicotine on small airways and arterial stiffness in a head-to-head design. This single-center, four-arm cross-overstudy included 20 healthy occasional smokers (25 ± 0.6 years). On four test days, participants consumed one product per day. Before, during, and after consumption, peripheral and central hemodynamic as well as arterial stiffness parameters were measured by Mobil-O-Graph™ (I.E.M., Germany). Resistance and small airway function were assessed by tremoFlo® c-100 (THORASYS Thoracic Medical Systems Inc.). The combustible cigarette and the e-cigarettes with and without nicotine significantly increased the resistance of the small airways (p < 0.05), while chewing bags had no effect. All nicotine containing products (e-cigarette with nicotine, combustible cigarette, chewing bag) as well as the e-cigarette without nicotine significantly increased parameters of hemodynamic and arterial stiffness. Changes in blood pressure and arterial stiffness were similar after smoking, vaping, and using chewing bags. We conclude that e-cigarettes and combustible cigarettes have similar acute harmful effects on small airway dysfunction. All nicotine containing products are associated with an increased cardiovascular risk compared with no product use. |
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| Item Description: | Gesehen am 14.04.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2305-6304 |
| DOI: | 10.3390/toxics11010077 |