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Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery

Reducing post-stroke disability is the major goal of stroke therapy. Consequently, functional testing is essential in experimental stroke studies to increase the predictive value of animal models. We used several sensory and motor tests to assess functional disability in a mouse model of permanent d...

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Main Authors: Lubjuhn, Judith (Author) , Gastens, Alexandra (Author) , von Wilpert, Gertrud (Author) , Bargiotas, Panagiotis (Author) , Herrmann, Oliver (Author) , Murikinati, Sasidhar (Author) , Rabie, Tamer (Author) , Marti, Hugo (Author) , Amende, Ivo (Author) , Hampton, Tom G. (Author) , Schwaninger, Markus (Author)
Format: Article (Journal)
Language:English
Published: 4 August 2009
In: Journal of neuroscience methods
Year: 2009, Volume: 184, Issue: 1, Pages: 95-103
ISSN:1872-678X
DOI:10.1016/j.jneumeth.2009.07.029
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneumeth.2009.07.029
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165027009004294
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Author Notes:Judith Lubjuhn, Alexandra Gastens, Gertrud von Wilpert, Panagiotis Bargiotas, Oliver Herrmann, Sasidhar Murikinati, Tamer Rabie, Hugo Marti, Ivo Amende, Tom G. Hampton, Markus Schwaninger
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Summary:Reducing post-stroke disability is the major goal of stroke therapy. Consequently, functional testing is essential in experimental stroke studies to increase the predictive value of animal models. We used several sensory and motor tests to assess functional disability in a mouse model of permanent distal middle cerebral artery occlusion (pdMCAO) that induced mainly cortical infarcts. Gait dynamics were transiently disturbed after pdMCAO as measured by different analysis techniques. Stance and brake duration were shorter after pdMCAO. Consistent with sensory and motor deficits the latency to move was prolonged up to 14 days after pdMCAO and the performance in the corner test and handedness were affected on day 1 or 2 after pdMCAO. Heart rate was decreased and heart rate variability were increased after pdMCAO indicating sympathetic-parasympathetic imbalance. In summary, pdMCAO-induced cortical infarcts lead to clinically relevant sensory, motor and cardiac autonomic dysfunction in mice. The present study provides a basis to explore the potential of functional testing for neuroprotection and neuroregeneration after stroke.
Item Description:Gesehen am 19.04.2023
Physical Description:Online Resource
ISSN:1872-678X
DOI:10.1016/j.jneumeth.2009.07.029

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