Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model
Leukocyte infiltration and activation of the CD40-CD40 ligand costimulatory pathway may promote inflammatory processes such as asthma. The aim of this study was to investigate whether a single intratracheal application of a decoy oligodeoxynucleotide (ODN) specific for signal transducer and activato...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 Mar 2010
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| In: |
Experimental lung research
Year: 2010, Volume: 36, Issue: 2, Pages: 85-93 |
| ISSN: | 1521-0499 |
| DOI: | 10.3109/01902140903144138 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3109/01902140903144138 Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.3109/01902140903144138 
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| Author Notes: | Anke Lührmann, Thomas Tschernig, Heiko von der Leyen, Markus Hecker, Reinhard Pabst, Andreas H. Wagner |
| Summary: | Leukocyte infiltration and activation of the CD40-CD40 ligand costimulatory pathway may promote inflammatory processes such as asthma. The aim of this study was to investigate whether a single intratracheal application of a decoy oligodeoxynucleotide (ODN) specific for signal transducer and activator of transcription (STAT) family members 1 and 3 influences leukocyte influx and pulmonary CD40 expression in a rat model of allergic airway inflammation. In comparison with the corticosteroid budesonide, the authors investigated the efficacy of the STAT decoy ODN in ovalbumin-induced allergic asthma in a Brown Norway rat asthma model. Leukocytes of the bronchoalveolar lavage (BAL) and lung tissue were analyzed and expression of CD40 was assessed by Western blotting. |
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| Item Description: | Gesehen am 19.04.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1521-0499 |
| DOI: | 10.3109/01902140903144138 |