Buchumschlag

Destruction of bacterial biofilms by polymorphonuclear neutrophils: relative contribution of phagocytosis, DNA release, and degranulation

Bacteria organized in biofilms are a common cause of relapsing or persistent infections, and the ultimate cause of implant-associated osteomyelitis. In these patients, biofilms of staphylococci are prevalent. Bacteria organized as biofilms are relatively resistant towards antibiotics and biocides, a...

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Bibliographische Detailangaben
Hauptverfasser: Meyle, Eva (VerfasserIn) , Stroh, Petra (VerfasserIn) , Günther, Frank (VerfasserIn) , Hoppe-Tichy, Torsten (VerfasserIn) , Wagner, Christof (VerfasserIn) , Hänsch, Gertrud Maria (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2010
In: The international journal of artificial organs
Year: 2010, Jahrgang: 33, Heft: 9, Pages: 608-620
ISSN:1724-6040
DOI:10.1177/039139881003300906
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/039139881003300906
Volltext
Verfasserangaben:Eva Meyle, Petra Stroh, Frank Günther, Torsten Hoppy-Tichy, Christof Wagner, G. Maria Hänsch
Beschreibung
Zusammenfassung:Bacteria organized in biofilms are a common cause of relapsing or persistent infections, and the ultimate cause of implant-associated osteomyelitis. In these patients, biofilms of staphylococci are prevalent. Bacteria organized as biofilms are relatively resistant towards antibiotics and biocides, and it is also assumed that they may escape host defense mechanisms. In this context, we have studied how polymorphonuclear neutrophils (PMN), the ?first line of defense? against bacterial infection, interact with biofilms generated in vitro. We found that PMN recognize biofilms and activate defense-associated reactions, including phagocytosis, degranulation of lactoferrin and elastase, and DNA release as well. Destruction of biofilms ensues, showing that biofilms are not inherently protected against the attack by phagocytic cells.
Beschreibung:Erstmals am 24. Januar 2018 online veröffentlicht
Gesehen am 20.04.2023
Im Titel wird der Verfasser "Torsten Hoppe-Tichy" fälschlich als "Torsten Hoppy-Tichy" angegeben
Beschreibung:Online Resource
ISSN:1724-6040
DOI:10.1177/039139881003300906

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