Virus-host interactomes and global models of virus-infected cells
Novel high-throughput technologies such as yeast two-hybrid and RNA interference (RNAi) screens provide the tools to study interactions between viral proteins and the host on a genomic scale. In this review, we provide an overview of studies in which these technologies were applied and of computatio...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Trends in microbiology
Year: 2011, Volume: 19, Issue: 10, Pages: 501-508 |
| ISSN: | 1878-4380 |
| DOI: | 10.1016/j.tim.2011.07.003 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tim.2011.07.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0966842X11001405 
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| Author Notes: | Caroline C. Friedel and Jürgen Haas |
| Summary: | Novel high-throughput technologies such as yeast two-hybrid and RNA interference (RNAi) screens provide the tools to study interactions between viral proteins and the host on a genomic scale. In this review, we provide an overview of studies in which these technologies were applied and of computational approaches for the analysis of the identified viral interactors in the context of the host cell. The results of these studies illustrate the advantages of integrative systems biology approaches in the investigation of viral pathogens. |
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| Item Description: | Gesehen am 24.04.2023 Online verfügbar: 18. August 2011 |
| Physical Description: | Online Resource |
| ISSN: | 1878-4380 |
| DOI: | 10.1016/j.tim.2011.07.003 |