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Correction to: Severe dysbiosis and specific haemophilus and neisseria signatures as hallmarks of the oropharyngeal microbiome in critically Ill coronavirus disease 2019 (COVID-19) patients

At the entry site of respiratory virus infections, the oropharyngeal microbiome has been proposed as a major hub integrating viral and host immune signals. Early studies suggested that infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with changes of the upp...

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Main Authors: Castilhos, Juliana de (Author) , Zamir, Eli (Author) , Wenz, Theresa (Author) , Rohrbach, Roman (Author) , Schmidt, Sabine (Author) , Hengler, Silvana (Author) , Schumacher, Hanna (Author) , Neubauer, Melanie (Author) , Kunz, Sabrina (Author) , Müller-Esch, Tonia (Author) , Hiergeist, Andreas (Author) , Geßner, André (Author) , Khalid, Dina (Author) , Gaiser, Rogier (Author) , Cullin, Nyssa (Author) , Papagiannarou, Stamatia M. (Author) , Beuthien-Baumann, Bettina (Author) , Krämer, Alwin (Author) , Bartenschlager, Ralf (Author) , Jäger, Dirk (Author) , Müller, Michael (Author) , Herth, Felix (Author) , Duerschmied, Daniel (Author) , Schneider, Jochen (Author) , Schmid, Roland M. (Author) , Eberhardt, Johann F. (Author) , Khodamoradi, Yascha (Author) , Vehreschild, Maria J. G. T. (Author) , Teufel, Andreas (Author) , Ebert, Matthias (Author) , Hau, Peter (Author) , Salzberger, Bernd (Author) , Schnitzler, Paul (Author) , Poeck, Hendrik (Author) , Elinav, Eran (Author) , Merle, Uta (Author) , Stein-Thöringer, Christoph (Author)
Format: Article (Journal)
Language:English
Published: 1 July 2022
In: Clinical infectious diseases
Year: 2022, Volume: 75, Issue: 1, Pages: 185
ISSN:1537-6591
DOI:10.1093/cid/ciac254
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1093/cid/ciac254
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Author Notes:Juliana de Castilhos, Eli Zamir, Theresa Hippchen, Roman Rohrbach, Sabine Schmidt, Silvana Hengler, Hanna Schumacher, Melanie Neubauer, Sabrina Kunz, Tonia Müller-Esch, Andreas Hiergeist, André Gessner, Dina Khalid, Rogier Gaiser, Nyssa Cullin, Stamatia M. Papagiannarou, Bettina Beuthien-Baumann, Alwin Krämer, Ralf Bartenschlager, Dirk Jäger, Michael Müller, Felix Herth, Daniel Duerschmied, Jochen Schneider, Roland M. Schmid, Johann F. Eberhardt, Yascha Khodamoradi, Maria J.G.T. Vehreschild, Andreas Teufel, Matthias P. Ebert, Peter Hau, Bernd Salzberger, Paul Schnitzler, Hendrik Poeck, Eran Elinav, Uta Merle and Christoph K. Stein-Thoeringer
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Summary:At the entry site of respiratory virus infections, the oropharyngeal microbiome has been proposed as a major hub integrating viral and host immune signals. Early studies suggested that infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with changes of the upper and lower airway microbiome, and that specific microbial signatures may predict coronavirus disease 2019 (COVID-19) illness. However, the results are not conclusive, as critical illness can drastically alter a patient’s microbiome through multiple confounders.To study oropharyngeal microbiome profiles in SARS-CoV-2 infection, clinical confounders, and prediction models in COVID-19, we performed a multicenter, cross-sectional clinical study analyzing oropharyngeal microbial metagenomes in healthy adults, patients with non-SARS-CoV-2 infections, or with mild, moderate, and severe COVID-19 (n = 322 participants).In contrast to mild infections, patients admitted to a hospital with moderate or severe COVID-19 showed dysbiotic microbial configurations, which were significantly pronounced in patients treated with broad-spectrum antibiotics, receiving invasive mechanical ventilation, or when sampling was performed during prolonged hospitalization. In contrast, specimens collected early after admission allowed us to segregate microbiome features predictive of hospital COVID-19 mortality utilizing machine learning models. Taxonomic signatures were found to perform better than models utilizing clinical variables with Neisseria and Haemophilus species abundances as most important features.In addition to the infection per se, several factors shape the oropharyngeal microbiome of severely affected COVID-19 patients and deserve consideration in the interpretation of the role of the microbiome in severe COVID-19. Nevertheless, we were able to extract microbial features that can help to predict clinical outcomes.
Several errors appeared in supplementary data for the corrected proof publication of this article (de Castilhos J, Zamir E, Hippchen T, et al. Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 [COVID-19] Patients. Clin Infect Dis; https://doi.org/10.1093/cid/ciab902).The publisher regrets these errors.
Item Description:Online veröffentlicht: 10. Mai 2022
Gesehen am 24.04.2023
Physical Description:Online Resource
ISSN:1537-6591
DOI:10.1093/cid/ciac254

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