Cover Image

Selective elimination of immunosuppressive T cells in patients with multiple myeloma

Elimination of suppressive T cells may enable and enhance cancer immunotherapy. Here, we demonstrate that the cell membrane protein SLAMF7 was highly expressed on immunosuppressive CD8+CD28-CD57+ Tregs in multiple myeloma (MM). SLAMF7 expression associated with T cell exhaustion surface markers and...

Full description

Saved in:
Bibliographic Details
Main Authors: Awwad, Mohamed (Author) , Mahmoud, Abdelrahman (Author) , Bruns, Heiko (Author) , Echchannaoui, Hakim (Author) , Kriegsmann, Katharina (Author) , Lutz, Raphael (Author) , Raab, Marc-Steffen (Author) , Bertsch, Uta (Author) , Munder, Markus (Author) , Jauch, Anna (Author) , Weisel, Katja (Author) , Maier, Bettina (Author) , Weinhold, Niels (Author) , Salwender, Hans Jürgen (Author) , Eckstein, Volker (Author) , Hänel, Mathias (Author) , Fenk, Roland (Author) , Dürig, Jan (Author) , Brors, Benedikt (Author) , Benner, Axel (Author) , Müller-Tidow, Carsten (Author) , Goldschmidt, Hartmut (Author) , Hundemer, Michael (Author)
Format: Article (Journal)
Language:English
Published: 17 February 2021
In: Leukemia
Year: 2021, Volume: 35, Issue: 9, Pages: 2602-2615
ISSN:1476-5551
DOI:10.1038/s41375-021-01172-x
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41375-021-01172-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41375-021-01172-x
Get full text
Author Notes:Mohamed H. S. Awwad, Abdelrahman Mahmoud, Heiko Bruns, Hakim Echchannaoui, Katharina Kriegsmann, Raphael Lutz, Marc S. Raab, Uta Bertsch, Markus Munder, Anna Jauch, Katja Weisel, Bettina Maier, Niels Weinhold, Hans Jürgen Salwender, Volker Eckstein, Mathias Hänel, Roland Fenk, Jan Dürig, Benedikt Brors, Axel Benner, Carsten Müller-Tidow, Hartmut Goldschmidt, Michael Hundemer
Description
Summary:Elimination of suppressive T cells may enable and enhance cancer immunotherapy. Here, we demonstrate that the cell membrane protein SLAMF7 was highly expressed on immunosuppressive CD8+CD28-CD57+ Tregs in multiple myeloma (MM). SLAMF7 expression associated with T cell exhaustion surface markers and exhaustion-related transcription factor signatures. T cells from patients with a high frequency of SLAMF7+CD8+ T cells exhibited decreased immunoreactivity towards the MART-1aa26-35*A27L antigen. A monoclonal anti-SLAMF7 antibody (elotuzumab) specifically depleted SLAMF7+CD8+ T cells in vitro and in vivo via macrophage-mediated antibody-dependent cellular phagocytosis (ADCP). Anti-SLAMF7 treatment of MM patients depleted suppressive T cells in peripheral blood. These data highlight SLAMF7 as a marker for suppressive CD8+ Treg and suggest that anti-SLAMF7 antibodies can be used to boost anti-tumoral immune responses in cancer patients.
Item Description:Gesehen am 24.04.2023
Physical Description:Online Resource
ISSN:1476-5551
DOI:10.1038/s41375-021-01172-x

Similar Items