Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions
Poliovirus 2B protein is a well-known viroporin implicated in plasma membrane permeabilization to ions and low-molecular-weight compounds during infection. Translation in mammalian cells expressing 2B protein is inhibited by hygromycin B (HB) but remains unaffected in mock cells, which are not perme...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 April 2010
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| In: |
Cellular microbiology
Year: 2010, Volume: 12, Issue: 8, Pages: 1144-1157 |
| ISSN: | 1462-5822 |
| DOI: | 10.1111/j.1462-5822.2010.01460.x |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1462-5822.2010.01460.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1462-5822.2010.01460.x 
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| Author Notes: | Vanesa Madan, Natalia Redondo and Luis Carrasco |
| Summary: | Poliovirus 2B protein is a well-known viroporin implicated in plasma membrane permeabilization to ions and low-molecular-weight compounds during infection. Translation in mammalian cells expressing 2B protein is inhibited by hygromycin B (HB) but remains unaffected in mock cells, which are not permeable to the inhibitor. Here we describe a previously unreported bystander effect in which healthy baby hamster kidney (BHK) cells become sensitive to HB when co-cultured with a low proportion of cells expressing poliovirus 2B. |
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| Item Description: | Gesehen am 25.04.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1462-5822 |
| DOI: | 10.1111/j.1462-5822.2010.01460.x |