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Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica

Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a lon...

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Main Authors: Mader, Simone (Author) , Lutterotti, Andreas (Author) , Pauli, Franziska Di (Author) , Kuenz, Bettina (Author) , Schanda, Kathrin (Author) , Aboul-Enein, Fahmy (Author) , Khalil, Michael (Author) , Storch, Maria K. (Author) , Jarius, Sven (Author) , Kristoferitsch, Wolfgang (Author) , Berger, Thomas (Author) , Reindl, Markus (Author)
Format: Article (Journal)
Language:English
Published: May 5, 2010
In: PLOS ONE
Year: 2010, Volume: 5, Issue: 5, Pages: 1-7
ISSN:1932-6203
DOI:10.1371/journal.pone.0010455
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0010455
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010455
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Author Notes:Simone Mader, Andreas Lutterotti, Franziska Di Pauli, Bettina Kuenz, Kathrin Schanda, Fahmy Aboul-Enein, Michael Khalil, Maria K. Storch, Sven Jarius, Wolfgang Kristoferitsch, Thomas Berger, Markus Reindl
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Summary:Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform.
Item Description:Gesehen am 25.04.2023
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0010455

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