Plasma iron controls neutrophil production and function

Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neutrophil production would be profoundly more iron-d...

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Bibliographic Details

Main Authors:	Frost, Joe (Author) , Wideman, Sarah K. (Author) , Preston, Alexandra E. (Author) , Teh, Megan R. (Author) , Ai, Zhichao (Author) , Wang, Lihui (Author) , Cross, Amy (Author) , White, Natasha (Author) , Yazicioglu, Yavuz (Author) , Bonadonna, Michael (Author) , Clarke, Alexander J. (Author) , Armitage, Andrew E. (Author) , Galy, Bruno (Author) , Udalova, Irina A. (Author) , Drakesmith, Hal (Author)
Format:	Article (Journal)
Language:	English
Published:	5 October 2022
In:	Science advances Year: 2022, Volume: 8, Issue: 40, Pages: 1-11
ISSN:	2375-2548
DOI:	10.1126/sciadv.abq5384
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.abq5384 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciadv.abq5384/
Author Notes:	Joe N. Frost, Sarah K. Wideman, Alexandra E. Preston, Megan R. Teh, Zhichao Ai, Lihui Wang, Amy Cross, Natasha White, Yavuz Yazicioglu, Michael Bonadonna, Alexander J. Clarke, Andrew E. Armitage, Bruno Galy, Irina A. Udalova, Hal Drakesmith