Plasma iron controls neutrophil production and function

Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neutrophil production would be profoundly more iron-d...

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Hauptverfasser: Frost, Joe (VerfasserIn) , Wideman, Sarah K. (VerfasserIn) , Preston, Alexandra E. (VerfasserIn) , Teh, Megan R. (VerfasserIn) , Ai, Zhichao (VerfasserIn) , Wang, Lihui (VerfasserIn) , Cross, Amy (VerfasserIn) , White, Natasha (VerfasserIn) , Yazicioglu, Yavuz (VerfasserIn) , Bonadonna, Michael (VerfasserIn) , Clarke, Alexander J. (VerfasserIn) , Armitage, Andrew E. (VerfasserIn) , Galy, Bruno (VerfasserIn) , Udalova, Irina A. (VerfasserIn) , Drakesmith, Hal (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 5 October 2022
In: Science advances
Year: 2022, Jahrgang: 8, Heft: 40, Pages: 1-11
ISSN:2375-2548
DOI:10.1126/sciadv.abq5384
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.abq5384
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciadv.abq5384/
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Verfasserangaben:Joe N. Frost, Sarah K. Wideman, Alexandra E. Preston, Megan R. Teh, Zhichao Ai, Lihui Wang, Amy Cross, Natasha White, Yavuz Yazicioglu, Michael Bonadonna, Alexander J. Clarke, Andrew E. Armitage, Bruno Galy, Irina A. Udalova, Hal Drakesmith
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Zusammenfassung:Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neutrophil production would be profoundly more iron-demanding than generation of other white blood cell types. ...
Beschreibung:Gesehen am 29.11.2023
Beschreibung:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.abq5384