Plasma iron controls neutrophil production and function
Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neutrophil production would be profoundly more iron-d...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 October 2022
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| In: |
Science advances
Year: 2022, Jahrgang: 8, Heft: 40, Pages: 1-11 |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abq5384 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.abq5384 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciadv.abq5384/ |
| Verfasserangaben: | Joe N. Frost, Sarah K. Wideman, Alexandra E. Preston, Megan R. Teh, Zhichao Ai, Lihui Wang, Amy Cross, Natasha White, Yavuz Yazicioglu, Michael Bonadonna, Alexander J. Clarke, Andrew E. Armitage, Bruno Galy, Irina A. Udalova, Hal Drakesmith |
| Zusammenfassung: | Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted that neutrophil production would be profoundly more iron-demanding than generation of other white blood cell types. ... |
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| Beschreibung: | Gesehen am 29.11.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abq5384 |