Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.

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Bibliographic Details
Main Authors:	Mueller, Stefanie H. (Author) , Arndt, Volker (Author) , Brenner, Hermann (Author) , Chang-Claude, Jenny (Author) , Kaaks, Rudolf (Author) , Surowy, Harald (Author) , Hamann, Ute (Author)
Format:	Article (Journal)
Language:	English
Published:	26 January 2023
In:	Genome medicine Year: 2023, Volume: 15, Pages: 1-18
ISSN:	1756-994X
DOI:	10.1186/s13073-022-01152-5
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13073-022-01152-5
Author Notes:	Stefanie H. Mueller, Volker Arndt, Hermann Brenner, Jenny Chang-Claude, Rudolf Kaaks, Harald Surowy, Ute Hamann [und viele weitere]

Description
Summary:	Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.
Item Description:	Gesehen am 28.04.2023
Physical Description:	Online Resource
ISSN:	1756-994X
DOI:	10.1186/s13073-022-01152-5