Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia
Our previous data suggested that angiopoietin-2 (Ang-2) is linked to pericyte loss, thereby playing an important role in diabetic retinopathy. In this study, we investigated the effect of retinal overexpression of human Ang-2 (mOpsinhAng2 mouse) on vascular morphology in non-diabetic and streptozoto...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
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| In: |
Acta diabetologica
Year: 2010, Jahrgang: 47, Pages: 59-64$i6 |
| ISSN: | 1432-5233 |
| DOI: | 10.1007/s00592-009-0099-2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00592-009-0099-2
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| Verfasserangaben: | Frederick Pfister, Yumei Wang, Kay Schreiter, Franziska vom Hagen, Karin Altvater, Sigrid Hoffmann, Urban Deutsch, Hans-Peter Hammes, Yuxi Feng |
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| 245 | 1 | 0 | |a Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia |c Frederick Pfister, Yumei Wang, Kay Schreiter, Franziska vom Hagen, Karin Altvater, Sigrid Hoffmann, Urban Deutsch, Hans-Peter Hammes, Yuxi Feng |
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| 520 | |a Our previous data suggested that angiopoietin-2 (Ang-2) is linked to pericyte loss, thereby playing an important role in diabetic retinopathy. In this study, we investigated the effect of retinal overexpression of human Ang-2 (mOpsinhAng2 mouse) on vascular morphology in non-diabetic and streptozotozin-induced diabetic animals. Pericyte (PC) coverage and acellular capillary (AC) formation were quantitated in retinal digest preparations after 3 and 6 months of diabetes duration. The degree of retinopathy in non-diabetic mOpsinhAng2 mice at 3 months (−21% PC, +49% AC) was comparable to age-matched diabetic wild type mice. Diabetic mOpsinhAng2 mice exhibited significantly worse vascular pathology than wild type counterparts at 6 months. Quantitative PCR revealed that human Ang-2 mRNA was highly overexpressed in retinas of transgenic mice. Our data demonstrate that overexpression of Ang-2 in the retina enhances vascular pathology, indicating that Ang-2 plays an essential role in diabetic vasoregression via destabilization of pericytes. | ||
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| 650 | 4 | |a Diabetic retinopathy | |
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