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Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts Novelty Seeking and Harm Avoidance

Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the...

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Bibliographic Details
Main Authors: Montag, Christian (Author) , Markett, Sebastian (Author) , Basten, Ulrike (Author) , Stelzel, Christine (Author) , Fiebach, Christian (Author) , Canli, Turhan (Author) , Reuter, Martin (Author)
Format: Article (Journal)
Language:English
Published: 21 April 2010
In: Neuropsychopharmacology
Year: 2010, Volume: 35, Issue: 9, Pages: 1860-1867
ISSN:1740-634X
DOI:10.1038/npp.2010.55
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/npp.2010.55
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/npp201055
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Author Notes:Christian Montag, Sebastian Markett, Ulrike Basten, Christine Stelzel, Christian Fiebach, Turhan Canli and Martin Reuter
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Summary:Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are mediated, in part, through dopaminergic mesolimbic circuitry. Carriers of the 66Met+/A1+ variant scored lowest on Novelty Seeking and highest on Harm Avoidance, compared to all other genotype groups. These participants are characterized by a relatively low D2 receptor density in the striatum and an impaired activity-dependent secretion of BDNF. This is one of the first genetic association studies to show a modulatory role for BDNF genetic variation on genetically mediated differences in the mesolimbic dopaminergic system in the context of human personality.
Item Description:Gesehen am 03.05.2023
Physical Description:Online Resource
ISSN:1740-634X
DOI:10.1038/npp.2010.55

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