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Secretogranin II influences the assembly and function of MHC class I in melanoma

Melanoma is the deadliest form of skin cancer showing rising incidence over the past years. New insights into the mechanisms of melanoma progression contributed to the development of novel treatment options, such as immunotherapies. However, acquiring resistance to treatment poses a big problem to t...

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Hauptverfasser: Steinfass, Tamara (VerfasserIn) , Poelchen, Juliane (VerfasserIn) , Sun, Qian (VerfasserIn) , Mastrogiulio, Giovanni (VerfasserIn) , Novak, Daniel (VerfasserIn) , Vierthaler, Marlene (VerfasserIn) , Pardo, Sandra (VerfasserIn) , Federico, Aniello (VerfasserIn) , Hüser, Laura (VerfasserIn) , Hielscher, Thomas (VerfasserIn) , Carretero, Rafael (VerfasserIn) , Offringa, Rienk (VerfasserIn) , Altevogt, Peter (VerfasserIn) , Umansky, Viktor (VerfasserIn) , Utikal, Jochen (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 11 March 2023
In: Experimental hematology & oncology
Year: 2023, Jahrgang: 12, Pages: 1-6
ISSN:2162-3619
DOI:10.1186/s40164-023-00387-1
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40164-023-00387-1
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Verfasserangaben:Tamara Steinfass, Juliane Poelchen, Qian Sun, Giovanni Mastrogiulio, Daniel Novak, Marlene Vierthaler, Sandra Pardo, Aniello Federico, Laura Hüser, Thomas Hielscher, Rafael Carretero, Rienk Offringa, Peter Altevogt, Viktor Umansky and Jochen Utikal
Beschreibung
Zusammenfassung:Melanoma is the deadliest form of skin cancer showing rising incidence over the past years. New insights into the mechanisms of melanoma progression contributed to the development of novel treatment options, such as immunotherapies. However, acquiring resistance to treatment poses a big problem to therapy success. Therefore, understanding the mechanisms underlying resistance could improve therapy efficacy. Correlating expression levels in tissue samples of primary melanoma and metastases revealed that secretogranin 2 (SCG2) is highly expressed in advanced melanoma patients with poor overall survival (OS) rates. By conducting transcriptional analysis between SCG2-overexpressing (OE) and control melanoma cells, we detected a downregulation of components of the antigen presenting machinery (APM), which is important for the assembly of the MHC class I complex. Flow cytometry analysis revealed a downregulation of surface MHC class I expression on melanoma cells that showed resistance towards the cytotoxic activity of melanoma-specific T cells. IFNγ treatment partially reversed these effects. Based on our findings, we suggest that SCG2 might stimulate mechanisms of immune evasion and therefore be associated with resistance to checkpoint blockade and adoptive immunotherapy.
Beschreibung:Gesehen am 03.05.2023
Beschreibung:Online Resource
ISSN:2162-3619
DOI:10.1186/s40164-023-00387-1

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