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Magel2 truncation alters select behavioral and physiological outcomes in a rat model of Schaaf-Yang syndrome

Previous studies in mice have utilized Magel2 gene deletion models to examine the consequences of its absence. We report the generation, molecular validation and phenotypic characterization of a novel rat model with a truncating Magel2 mutation modeling variants associated with Schaaf-Yang syndrome-...

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Main Authors: Reznik, Derek (Author) , Yang, Mingxiao V. (Author) , Albelda de la Haza, Pedro (Author) , Jain, Antrix (Author) , Spanjaard, Melanie (Author) , Theiß, Susanne (Author) , Schaaf, Christian P. (Author) , Malovannaya, Anna (Author) , Strong, Theresa V. (Author) , Veeraragavan, Surabi (Author) , Samaco, Rodney C. (Author)
Format: Article (Journal)
Language:English
Published: February 2023
In: Disease models & mechanisms
Year: 2023, Volume: 16, Issue: 2, Pages: 1-18
ISSN:1754-8411
DOI:10.1242/dmm.049829
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1242/dmm.049829
Verlag, kostenfrei, Volltext: https://journals.biologists.com/dmm/article/16/2/dmm049829/286899/Magel2-truncation-alters-select-behavioral-and
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Author Notes:Derek L. Reznik, Mingxiao V. Yang, Pedro Albelda de la Haza, Antrix Jain, Melanie Spanjaard, Susanne Theiss, Christian P. Schaaf, Anna Malovannaya, Theresa V. Strong, Surabi Veeraragavan and Rodney C. Samaco
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Summary:Previous studies in mice have utilized Magel2 gene deletion models to examine the consequences of its absence. We report the generation, molecular validation and phenotypic characterization of a novel rat model with a truncating Magel2 mutation modeling variants associated with Schaaf-Yang syndrome-causing mutations. ...
Item Description:Online veröffentlicht am 3. Februar 2023
Gesehen am 05.12.2023
Physical Description:Online Resource
ISSN:1754-8411
DOI:10.1242/dmm.049829

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