Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer’s disease?
An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic ac...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
07 December 2010
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| In: |
Journal of neural transmission
Year: 2010, Volume: 117, Issue: 12, Pages: 1419-1422 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s00702-010-0523-3 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00702-010-0523-3
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| Author Notes: | Konstanze Plaschke, Dorothea Müller, Siegfried Hoyer |
| Summary: | An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic acid in temporal cortex; and of palmitic acid in entorhinal cortex indicative of membrane phospholipid breakdown, and damage of the membrane structure. The relevance of these changes is discussed in relation to sporadic Alzheimer’s disease. |
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| Item Description: | Gesehen am 04.05.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s00702-010-0523-3 |