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Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice

Rhythmic breathing movements originate from a dispersed neuronal network in the medulla and pons. Here, we demonstrate that rhythmic activity of this respiratory network is affected by the phosphorylation status of the inhibitory glycine receptor α3 subtype (GlyRα3), which controls glutamatergic and...

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Main Authors: Manzke, Till (Author) , Niebert, Marcus (Author) , Koch, Uwe R. (Author) , Caley, Alex (Author) , Vogelgesang, Steffen (Author) , Hülsmann, Swen (Author) , Ponimaskin, Evgeni (Author) , Müller, Ulrike C. (Author) , Smart, Trevor G. (Author) , Harvey, Robert J. (Author) , Richter, Diethelm W. (Author)
Format: Article (Journal)
Language:English
Published: October 11, 2010
In: The journal of clinical investigation
Year: 2010, Volume: 120, Issue: 11, Pages: 4118-4128
ISSN:1558-8238
DOI:10.1172/JCI43029
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1172/JCI43029
Verlag, kostenfrei, Volltext: https://www.jci.org/articles/view/43029
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Author Notes:Till Manzke, Marcus Niebert, Uwe R. Koch, Alex Caley, Steffen Vogelgesang, Swen Hülsmann, Evgeni Ponimaskin, Ulrike Müller, Trevor G. Smart, Robert J. Harvey, and Diethelm W. Richter
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Summary:Rhythmic breathing movements originate from a dispersed neuronal network in the medulla and pons. Here, we demonstrate that rhythmic activity of this respiratory network is affected by the phosphorylation status of the inhibitory glycine receptor α3 subtype (GlyRα3), which controls glutamatergic and glycinergic neuronal discharges, subject to serotonergic modulation.
Item Description:Gesehen am 04.05.2023
Physical Description:Online Resource
ISSN:1558-8238
DOI:10.1172/JCI43029

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