Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice
Rhythmic breathing movements originate from a dispersed neuronal network in the medulla and pons. Here, we demonstrate that rhythmic activity of this respiratory network is affected by the phosphorylation status of the inhibitory glycine receptor α3 subtype (GlyRα3), which controls glutamatergic and...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 11, 2010
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| In: |
The journal of clinical investigation
Year: 2010, Jahrgang: 120, Heft: 11, Pages: 4118-4128 |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI43029 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1172/JCI43029 Verlag, kostenfrei, Volltext: https://www.jci.org/articles/view/43029 |
| Verfasserangaben: | Till Manzke, Marcus Niebert, Uwe R. Koch, Alex Caley, Steffen Vogelgesang, Swen Hülsmann, Evgeni Ponimaskin, Ulrike Müller, Trevor G. Smart, Robert J. Harvey, and Diethelm W. Richter |
| Zusammenfassung: | Rhythmic breathing movements originate from a dispersed neuronal network in the medulla and pons. Here, we demonstrate that rhythmic activity of this respiratory network is affected by the phosphorylation status of the inhibitory glycine receptor α3 subtype (GlyRα3), which controls glutamatergic and glycinergic neuronal discharges, subject to serotonergic modulation. |
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| Beschreibung: | Gesehen am 04.05.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI43029 |