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Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

The Nek2 kinase directs the separation of duplicated centrosomes. Now the Hippo pathway components hSav1 and Mst2 are shown to regulate the function of Nek2 at the centrosome. This pathway cooperates with the kinesin Eg5 to mediate centrosome separation.

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Bibliographic Details
Main Authors: Mardin, Balca (Author) , Kellner, Cornelia (Author) , Baxter, Joanne E. (Author) , Hardy, Tara (Author) , Scholz, Sebastian Richard (Author) , Fry, Andrew M. (Author) , Schiebel, Elmar (Author)
Format: Article (Journal)
Language:English
Published: 14 November 2010
In: Nature cell biology
Year: 2010, Volume: 12, Issue: 12, Pages: 1166-1176
ISSN:1476-4679
DOI:10.1038/ncb2120
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncb2120
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncb2120
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Author Notes:Balca R. Mardin, Cornelia Lange, Joanne E. Baxter, Tara Hardy, Sebastian R. Scholz, Andrew M. Fry and Elmar Schiebel
Description
Summary:The Nek2 kinase directs the separation of duplicated centrosomes. Now the Hippo pathway components hSav1 and Mst2 are shown to regulate the function of Nek2 at the centrosome. This pathway cooperates with the kinesin Eg5 to mediate centrosome separation.
Item Description:Das PDF enthält zusätzlich einen Anhang von 12 Seiten
Gesehen am 04.05.2023
Physical Description:Online Resource
ISSN:1476-4679
DOI:10.1038/ncb2120

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